Scientific journal
European Student Scientific Journal
ISSN 2310-3094

Personal portfolio

ACTION OF METHYLURACIL OINTMENT ON LEVEL OF PROINFLAMMATORY CYTOKINES IN BURN WOUND AT RATS

Krivoshapka A.V. 1 Berezhnaya A.V. 2 Mironchenko S.I. 2
1 Kharkov national medical university
2
Experimental research has shown that pro-inflammatory cytokines IL-1β, TNF-α and IL-8 influence the course and outcome of inflammatory and reparative processes of burn wounds. It is shown that the development is characterized by severe thermal burns and prolonged increase marker proinflammatory cytokines IL-1β (for 3 weeks of observation), TNF-α and IL-8 (28 days) in the blood and supported against the reparative regeneration, slow wound healing . Evidence of the pro-inflammatory cytokines in the mechanisms of chronic burn wounds involvement is the data, which was obtained as a result of a wound healing using the medicament ointment " Methyluracyl ." Its use reduces the period of cytokine activity in the blood (normalization of IL-1β and IL- 8 on day 14 , TNF-α - day 21), which leads to acceleration of burn wounds healing.
healing
methyluracil ointment
proinflammatory cytokines
burn wound