Scientific journal
European Student Scientific Journal
ISSN 2310-3094
ISSN 2310-3094
THE ROLE OF MATRIX METALLOPROTEINASES IN HEALING OF BURN WOUNDS
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Matrix metalloproteinases take a special role in the course of wound process, particularly in burn wounds healing. This process participates in proteoclastic degradation of different components of extracellular matrix and facilitates to regulating and modulating function in angiogenesis. Substrates of matrix metalloproteinases are growth factor, proteases, adhesive molecule and extracellular matrix component. Tissue inhibitors of matrix metalloproteinases are the principal inhibitors of matrix metalloproteinases in tissues and have focal function in maintaining this balance. Specific interaction between matrix metalloproteinases and their tissue inhibitors is the key point in regulation of re-molding tissues. Angiogenesis has significant meaning in the course of wound process. The process of new vessels forming requires preliminary proteolysis extracellular matrix, proliferation and migration of endothelial cell and also fusion of new matrix components. If angiogenesis is insufficient so fibroblast migration stops and vulnerary healing process ceases. The role of metalloproteinases as the regulators is connected with balance of angiogenic and angiostatic factors. Imbalance between angiogenic agents and anti-angiogenic agents provides a key avenue of chronisation of the process.
matrix metalloproteinases
wound process
burn wounds.